triplet code การใช้

• Each of those triplets codes for a specific amino acid.
• Some amino acids might have multiple triplet codes.
• However, recent research suggests that such alterations to the triplet code do effect protein translation efficiency and protein folding and function.
• Proof that the genetic code is a degenerate triplet code finally came from genetics experiments, some of which were performed by Crick.
• Thus, they concluded that the genetic code is a triplet code because it did not cause a frameshift in the reading frame.
• Silent mutations lead to a change of one of the letters in the triplet code that represents a codon, but despite the single base change, the amino acid that is coded for remains unchanged or similar in biochemical properties.
• With his colleague Sydney Brenner, Crick eventually proved, in an experiment of remarkable elegance, that the genetic code was a triplet code in which sets of three bases in the DNA sequence determine a corresponding sequence of amino acids in proteins.
• With his colleague Sydney Brenner, Crick eventually proved, in an experiment of remarkable elegance, that the genetic code was a comma-less, triplet code in which sets of three bases in the DNA sequence determine a corresponding sequence of amino acids in proteins.
• Once it was established that the genetic code was a triplet code, and since it was known that there are only 4 types of base in DNA ( A, T, G and C ), it could be deduced that there are 64 possible triplets ( codons ) ( 4 x 4 x 4 = 64 ).
• Crick, Brenner, Klug and Pieczenik returned to their early work on deciphering the genetic code with a pioneering paper on the origin of protein synthesis, where constraints on mRNA and tRNA co-evolved allowing for a five-base interaction with a flip of the anticodon loop, and thereby creating a triplet code translating system without requiring a ribosome.
• In his molecular biology period, Benzer dissected the fine structure of a single gene, laying down the ground work for decades of mutation analysis and genetic engineering, and setting up a paradigm using the " rII " phage that would later be used by Francis Crick and Sidney Brenner to establish the triplet code of DNA . In addition, Benzer's mapping technique was taken up by Richard Feynman.